1.Effects Of Intraocular Lenses Of Different Materials On Posterior Capsule Opacification: A Systematic Review 2.Screening Of Genes Causing Autosomal Dominant Lamellar Cataract In A Chinese Family

Objective To evaluate the effects of intraocular lenses (IOL) of different materials on posterior capsule opacification (PCO)Materials and Methods A Cochrane systematic review of clinical controlled trials of effects of intraocular lenses of different materials on posterior capsule opacification was performed. Trials were identified by searching for the following electronic database for clinical controlled trials about PCO: Chinese Biomedicine Database (CBM), MEDLINE, EMBASE and Cochrane Controlled Trials Register. Two reviewers independently assessed the quality of the included trails and extracted data independently. The following outcomes were assessed: posterior capsule opacification (PCO) index, percentage of neodymium: YAG (Nd:YAG), and visual acuity after cataract surgery. Applied RevMan 4.2 for statistical analysis. Results Twenty clinical controlled trials with 2577 eyes (2324 patients) were included. Five kinds of intraocular lens materials were: PMMA (polymethylmethacrylate), Acrysof, Silicone, hydrogel, and HSM-PMMA(heparin- surface- modified PMMA). Meta-analysis was performed. (1) Ten trials compared Acrysof with Silicone, combined analysis showed Acrysof was better than Silicone: about the total PCO index, there was a statistically significant difference in favor of Acrysof (p=0.02); the percentage of Nd:YAG of Acrysof was lower than that of Silicone, there was significant difference between the two groups(p < 0.0001); about visual acuity after cataract surgery Acrysof was superior to Silicone, there was significant difference between the two groups(p=0.001) (2)Eight trials compared Silicone with PMMA, combined analysis showed Silicone was better than PMMA: about the total PCO index, there was a statistically significant difference in favor of Silicone (p=0.0.001); the percentage of Nd:YAG of Silicone was lower than that of PMMA, there was significant difference between the two groups(p < 0.0001); about visual acuity after cataract surgery there was a non-significant trend in favor of Silicone (p=0.27). (3) Four trials compared HSM-PMMA with PMMA: about the total PCO index, there was a non-significant trend in favor of HSM-PMMA (p=0.25); the percentage of Nd.YAG of HSM-PMMA was lower than that of PMMA; There was no significant difference between the two groups in visual acuity after cataract surgery(p=0.80) (4)Three trials compared hydrogel with sicilone: there was no significant difference between the two groups in percentage of Nd:YAG(p=0.08).Conclusion Different materials of IOL have different effects on PCO. Of these five kinds of materials, Acrysof is the best, Silicone is better than PMMA, additionally, HSM-PMMA is better than PMMA. According to data we collecte presently, There is no significant difference between hydrogeland sicilone. However, because the quality of the included trails was not high, we should adopt the conclusion cautiously. More trails with sound methodology and standardized evalution measures of PCO are required.