Impact Of Renal Function At Early Stage After Transplantation On The Prognosis In Near Future

Objective: To summarize the relativity between renal function at early stage after transplantation and the prognosis of kidney in the near future. We want to forecast the prognosis of kidney in the near future accurately by observing their function status early after operation and to help making measures both pre- and post-transplantation to improve the near prognosis according to the forecast. Method: To summarize the data of the patients who received renal transplantation and adopted CsA as one of the drugs for immunity inhibition treatment after operation from 1996 to 2003.6 at urology department in West China hospital of Si Chuan University. Divide these cases into 4 teams due to their serum creatine level at 12 hours after transplantation and analyse ingredients such as receptor'age , donor kidney'quality, operation process and other factors which can make effects on prognosis. Record and compare the graft function status at 7, 30, 90days after transplantation and instances of acute rejection and CsA renal toxicosis. Results: Patients whose SCr≤300umol/L have notably higher normal renal function ratio(80.30%) at 7 days after transplantation; patients whose SCr≤500umol/L have notably higher normal renal function ratio (87.28%,94.74%)at 30> 90days after transplantation; patients whose SCr<500umol/L have better degree to which their grafts function recoverd at 3(K90days after transplantation; patients whose SCr<500umol/L have notably lower ratio of acute rejection(13.60%> 16.23%) and delayed graft function(2.63%) during the period which is 30 and 90 days after transplantation, no difference has been found in the 4 teams on the ratio of definitely diagnosed CsA renal toxicosis; further more, patients whose urine volume is less than 1000ml when 12h passed after transplantation have poor near prognosis and almost 70% of DGF^ AGF patients who failed to recover lose their grafts during 30 days after transplantation. Conclusion: Making measures both to promote graft function to recover smoothly to the degree that SCr<500umol/L and to increase urine volume to more than 3000ml(250ml/h) at the point of 12h after transplantation may benefit the prognosis of graft in the near future.