The Characters And Clinical Significance Of T Lymphocyte Subsets In Peripheral Blood Of New Cases With Osteoarticular Tuberculosis

Objectives: to investigate the features, changes of T lymphocyte subsets of new cases with osteoarticular tuberculosis before and after antituberculosis treatment and to investigate their correlations to clinical factors. To provide basis for clinical work for correctly evaluating the lymphocyte subset values in peripheral blood of new cases with osteoarticular tuberculosis.Methods: both absolute counts and percentages of lymphocyte subsets in peripheral blood of new cases with osteoarticular tuberculosis were detected by single-plateform flow cytometry. T lymphocyte subsets in Peripheral Blood of new cases with osteoarticular tuberculosis were compared with those from 18 patients with malignant primary or metastatic bone tumor and 52 normal controls. The correlations of T lymphocyte subsets values of peripheral blood to several clinical factors of new cases with osteoarticular tuberculosis were analyzed. The T lymphocyte subsets values in peripheral blood of patients with osteoarticular tuberculosis between pre-treatment and one month post-treatment were compared.Results: fifty-two new cases with osteoarticular tuberculosis, eighteen patients with malignant primary or metastatic bone tumor and fifty-two normal controls wererecruited. The levels of absolute counts of CD45+, CD3+, CD4+ and CD8+ cells in new cases with osteoarticular tuberculosis were significantly lower than those in normal controls and in malignant bone tumors. The levels of absolute counts andpercentage of CD8+ T lymphocytes in adolescent patients were significantly higher than those in middleaged and elderly patients. The levels of percentage of CD3+...