Relation Between Body Composition, Leptin, Sex Hormone And BMD In Middle-aged And Aged Men

Objective: The incidence of aged osteoporosis (OP) in men was lower than that in women. However, with the extension of human life span, the incidence of male OP had been increasing as that of women OP year by year. Most of the studies in this area have been in women while the pathogenesis difference between OP in men and women was not known. Body weight are closely related to bone mass and various hormones may be involved in this relationship. In order to understand the pathogenesis of male OP and early find susceptible people for OP and thus conduct preventive measures, we had studied the impact of body composition, circulatory leptin(LEP), testosterone(Tes), estradiol(E2) and insulin (INS) levels on bone mineral density (BMD) in middle-aged and aged men.Methods: 1. We measured BMD at lumber spine2⁴(L2-4) and total(TOT) bone and body composition by dual energy X-ray absorptiometry(DXA) in 82 middle-aged and aged men, 106 middle-aged and aged women were controlled. 2. Fasting serum LEP, Tes, E₂ and INS concentration were measured in 82 apparently healthy men by Radioimmunoassay(RIA).Results: 1. (1)We founded that fat mass (FM), fat-free mass (FFM) were all positively correlated with BMD at lumer spine(male FM: r =0.259, P=0.046, male FFM: r =0.266, P=0.041; female FM: r =0.364, P=0.016, female FFM: r=0.273, P=0.036) and total bone(maleFM: r=0.315, P=0.012, male FFM:...