Clinical Study Of Pulse-activating Injection Effects On Urinary Excretion Of Digoxin In Patients With Heart Failure

ObjectiveTo study the effects of Pulse-activating Injection (PAI) on the urinary excretion of digoxin in patients with heart failure.Methods40 inpatients, with the cardiac functions of level II -III (NYHA) and no applications of any digitalis preparations and any preparations those can affect the pharmacokinetic of cardiox in the latest week, without obviously liver and renal disfunctions and electrolyte disturbances, were randomly divided and delaminated by age into four groups: three trial groups ( 5% glucose solution 100ml + R-I lu + KC10.25g + Pulse-activating Injection 20ml, 40ml or 60ml iv drip qd X 7, n=l 0 in each group ) and the control one ( 5% glucose solution 100ml + R-I lu + KC10.25g iv drip qdX7, n=10 ). The digoxin injection (0.25mg iv.st) was given to every group once when the 5% glucose solution was dripped for 0.5 hour at the first time. The 24-hour urine were collected and counted before administration and after that for 7 days, with 4ml of the urine of those days frozen and kept to be determined for digoxin concentration in urine by radio-immunity assay (RIA). Urinary excretion of digoxin in each specified time interval was calculated by multiplying digoxin urine concentration by urine volume voided in that particular time period. The urine volume and urinary excretion of digoxin in different time period were compared between different groups. Results:1 .Compared within groupsThere were significant difference between the urine volume of the day before administration and those of 7days after administration (P<0.01).2.Compared between groups(1)Compared between the low-dosage group of PAI and the control oneThe urine volume of low-dosage group of PAI were both significantly higher than those of the control one in the 1st and 2nd day (P<0.01); The 24-hour urinary excretion of digoxin of low-dosage group of PAI were both significantly higher than those of the...