An Experimental Study On Material Properties Of Domestic Polyvinyl Alcohol

There are two parts in our study. Biocompatibility of domestic polyvinyl alcohol particles and Embolic properties in artery were investigated to evaluate the feasibility and safty of using PVA in human arteries.Part 1: An experimental research on biocompatibility of domestic polyvinyl Alcohol particlesObjective To study the histopathologic changes of domestic polyvinyl alcohol particles after implanted into back muscle of the rabbits .Methods The domestic PVA was implanted in one side of the back muscle of ten rabbits. meanwhile in contralateral side the imported PVA was implanted .The postoperative local histopathologic changes were observed at 1 , 4, 12, 26 , 52 weeks. Results There was no significant inflammation occurred.Local hypodermic and muscular tissue were normal when observed by eyes. All postoperative histopathologic changes were within the authoritative ranges. Conclusion The histo-compatibility of domestic PVA is favorable.Part 2: An experimental research on embolic properties of domestic polyvinyl Alcohol particlesObjective To evaluate the effects of a granular embolic agent consistingof domestic polyvinyl alcohol (PVA) and to compare this agent with commercially available embolization agents.Methods Fifteen dogs were included in the study population,The upper poles of both kidneys were selected as the target organs for embolization.The domestic PVA particles(255-355um)were used in the upper poles of fifteen left kidneys, The import PVA(255-355um) were used in the upper poles of fifteen right kidneys. Three dogs were killed immediately after embolization. In the remaining animal.angiography was performed before sacrifice lweek>4weeks> 12weeks> 26weeks after embolization. Respectively pathologic and histologic evaluation of the kidneys was performed. Result Tow agents resulted in target vessel occlusion and end-organ infarction. All arteriae embolized with these two kinds of particles were recanalized at follow-up angiograply .In vessels embolized with these two PVA particles ,the occluding plug consisted of thrombus and PVA particles. The domestic PVA particles were associated with the same inflammatory responses compared with imported PVA particles (P>0.05). Arterial wall destruction was seen to a greater extent in kidneys embolized with domestic PVA particles at 0 week compared with imported PVA particles (P<0.05),After 1 week it has the same arterial wall destruction with import PVA(P>0.05) .Conclusions The domestic PVA particles have similar properties with the import PVA particles.lt s feasible to use domestic PVA as embolic agent in arteries.