The Effect Of Liver Homogenate Filtrate On Heterotopic Transplanted Hearts In The Rat

【Objective】To research into the effect of liver homogenate filtrate onlymphocyte function and heterotopic transplanted hearts in the rat.【Methods】We made liver homogenate filtrate. One-way mixedlymphocyte reaction (MLR) was determined by means of MTT in rats ofdifferent groups. After transplanting heart in abdominal cavity, thetransplanted heart beating time was observed in different rat groups.When heart-beating stopped, we resected the transplanted hearts toexamine their pathology and immunohistochemistry.【Results】Liver homogenate filtrate suppressed MLR remarkably(P<0.01). The transplanted hearts in rats who had been injected liverhomogenate filtrate (38.05±17.07d) beat longer than the control group(9.45±2.01d), their hemorrhage and necroses were lessened, with lessdeposition of IgM and IgG.【Conclusion】Liver homogenate filtrate suppresses MLR specificallyin vivo, lessens reject reaction of transplanted hearts in rats, prolongstheir beating .