Clinical Study On The Pathologic Changes Of Palatopharyngeal Muscle In The Patiens With Obstructive Sleep Apnea Syndrome

Objctive To study the pathologic changes of the palatopharyngeal muscle in patients with OSASMethods Different analyses have been done on the palatopharyngeal muscles in patients with 0SAS(n=31)and controls (n=ll) . the sections were sequentially stained for HE, myofibrilar Troponin I Antibody. All speciments were evaluated by transmission election microscopy (TEM). Rsults 29 of 30patients with OSAS that evaluated by transmission election microscopy (TEM) have significiently different degree pathologic changes. While 2 among 10 controls have lightly myofibrilar edema or hypertrophy, the others have not any pathologic changes (p<0.05). Immunohistochemistorical results of all specimens sections stained for TropninI Antibody have shown that mean negnative grey degree evaluations are 146. 2989±10.7249 and 107.5014+4.8065 in both groop of study and controls respectively(p<0.05). semi-quantitive analyses on TropninI have been shown that 7 specimens of the patiens with OSAS are positive,1 case strongly positive;8 specimens of the controls are strongly positive, 3 positive.Conclution Our study suggest that myofibrilar pathologic chages and functional disturbance of palatopharyngeal muscles(pharyngeal dilator muscles)may play an important role in causing the supper airway collapse in OSAS.