Study On The Relation Of Blood Transfusion And Hepatitis B Virus Hepatitis C Virus

As an important part of clinical medicine, blood transfusion played a very important role in saving lives in past decades years. But transfusion can cause very serious diseases such as hepatitis B and hepatitis C at the same time. The same traits of hepatitis B virus (HBV) and hepatitis C virus (HCV) are strong infective and harmful to people. In order to master the hepatitis B and hepatitis C epidemic situation in our city, to analyse the risk factors. Survey the relation between transfusion and infection of hepatitis B(HB) and hepatitis C(HC).In order to provide reliable and general datum for the steps of prevention of hepatitis B and hepatitis C , through questionary and medical record inquiry, writer investigate general traits(such as age,sex,marriage,native,career) of 887 in-patients and infection information of HBV\HCV in our hospital from 2004, January to 2005,August.Survey transfusion history of 887 cases and relevant infection rate of HBV and HCV; Survey different transfusion times and relevant infection rate of hepatitis B virus and hepatitis C virus; Survey the history of transfusion operation donation blood hemodialysis of 887cases and infection rate of all kinds of history ,investigate all kinds of affection factors of HBV infection and HCV infection .Investigate infection rate of HBV in hematophy and others wards; Analyse the immunity model of HBV infection among 887 in-patients. In the course of investigation ,adopting random principle, using united questionary by trained investigator, one investigator to one patient, record information timely.. Lab inspection: HBC inspection(5 items of immunity marks):adopt method of ELISA to inspect patients` serum. HCV inspection: adopt methods of ELISA and FQ-PVR to inspect patients` serum. Draw conclusions from above datum : 1.There is no relevant relation between in-patients'general traits(such as age,sex,marriage,career,native) and infection of HBV and HCV. 2 . There is statistical difference between transfusion group and non-transfusion group, that is to say transfusion can increase possibility of infection of HBV and HCV. 3.In the course of the survey of relation between transfusion times and HBC infection ,we find transfusion times increase, at the same time the infection rate of HBV increase too, through x2 inspection of line×row sheet .draw: P<0.05 that is to say when transfusion times is different ,the infection rate of HBV is obviously different too. 4.During the investigation course of all kind of risk factors, the HBV infection rate of the patients who have transfusion experience comes up to 10.6%, the HBV infection rate of the patients who both have transfusion and operation experience is 18.2%, the other group is 3.3%, it indicate that transfusion is the major transmission approach of HBV, but not the only one. Besides definite experience as operation hemodialysis transmission and donation, HBV can be transmitted by sex, mum-baby, contact and so on. The operation group patients` infection rate is 5.1% statistically .It is lower than average infection rate (6.5%), demonstrate that antisepsis of operate appliance is severe, pollution of appliance is not the major infection approach of HBVany more, HBV infection rate of operation and transfusion group is 18.2% much higher than operation group. 5.We developed the risk factors research of HCV infection. The HCV infection rate is 2.6% among the patients with the history of transfusion and operation, which is higher than the patients who operated and accept blood or blood materials, this indicates that transfusion can increase the possibility of HCV infection . 6.The positive rate of B hepatitis and C hepatitis varied in hematopathy ward and other wards. For example , the positive rate of hepatitis B in hematophy ward is 21.2% , which is the highest. It is possible caused by lony disease course and transfusion more times .The patients there often get more chance to transfusion and accepting blood components. This datum show that transfusion is highly related to HBV and HCV infection. 7.The number of research case is 887, among them there are 568 persons who are negative of hepatitis B which make up 64%. The number of only anti-HBS positive is 261,which make up 29.4%. In the five items of HBV, only anti-HBS is useful to prevent infection which generated by active and passive immunity. Other patterns is 58 cases, making up 6.5%. The infection rate of hepatitis B is 6.5%. We can conclude that the blood with HBeAg and HBcAb is most risk to transmit HBV. If the proportion of antigen and antibody is not appropriate, as to say, highest concentration of HBsAg can appear to be negative for HBsAg in ELISA test. IN our study , there is only one care of this model, making up 0.1%, but it is more danger to the persons who obtain this blood. We conclude that it is not enough to detect only HBsAg in blood donor. 8.Survey the causes of transfusion among 179 cases who had transfusion history. 10 cases of 179 cases (6% of total cases )have notransfusion request, we can see that large part of clinic doctors transfuse blood for patients can according to transfusion regulations, but a small part of doctors do not transfuse blood for patients of right Our study investigated the pervasion and infection occurrence of hepatitis B and hepatitis C. Demonstrated the relationship of HBV/HCB infection and blood transfusion. Argument the harm and transmit ways of HBV and HCV . Reserch how to decrease the occurrence rate of hepatitis B and hepatitis C. Suggest the patients must be test before transfusion and operation. Argument the reason which we can't prevent the transmission completely. We introduce that we should detect all five items of HBV rather than HBsAg only in blood donors. And we should detect anti-HCV and HCV-RNA to screen. HCV in blood donor to obtain security in blood transfusion.