Treatment Of Hyperthyroidism Complicated With Severe Hepatitis With ～(131)I Plus Artificial Liver Support System

Objective To assess the safety as well as the clinical application of ¹³¹I plus artificial liver support system (ALSS) in the treatment of hyperthyroidism complicated with severe hepatitis.Methods 43 patients with hyperthyroidism complicated with severe hepatitis were divided into two groups According to their different treatments: 18 cases were treated with anti-thyroid drugs (ATD) as group A and 25 cases with ¹³¹I therapy as group B, on the basis of hepatinica and heteropathy. Of the group B, 12 cases were treated without artificial liver support system (ALSS) but conventional therapy only as group B1, while 12 cases with ALSS as group B2. Both the thyroid function and liver function were tested before and after the treatments, and the clinical symptoms were observed. The cure and improved rate were compared among group A and B, and the cure rate were compared among group B1 and B2, respectively. Moreover, the changes of serum level of FT3, FT4, TSH, Tbil, Dbil, TBA, AST and ALT were observed, before and after each ALSS therapy, respectively.Results The cure and improved rate of group B (96.0%) was significantly higher than that of group A (61.1 %) , and the cure rate of group B2 (84.6%) was significantly higher than that of group Bl (33.3%), P<0.05. Serum level of FT3, FT4, Tbil, Dbil, AST and ALT decreased obviously after ALSS therapy, P<0.05.Conclusion To control hyperthyroidism rapidly is the key in the treatment of hyperthyroidism complicated with severe hepatitis. Compared with ATD, ¹³¹I has more therapeutic effect. ALSS could improve the safety and cure rate in the treatment. The clinical application of ¹³¹I plus artificial liver support system (ALSS) in the treatment of hyperthyroidism complicated with severe hepatitis is worth popularizing.