Clinical Observation Of Intrapleural Injection Of Urokinase Forpatients With Encapsulated Tuberculous Pleural Effusion

Objective To determine the effects of intrapleural injection of urokinase for patients with encapsulated tberculous pleural effusion.Methods Regular antituberculosis treatment was given to all patients observed.Urokinase and INH were injected 50 OOOU/day and 300mg/day respectively into the pleural cavity of 21 patients with encapsulated tuberculous pleural effusion for 5 days. While prednisolone of 125mg/day plus INH of 300mg/day were injected into the pleural cavity of 14 patients of the control hroup.Results 94.3%(19/21)of the 21 cases of the study hroup achieved complete improvement and another 5.7%(2/21) of the studied cases achieved partial improvement.While in control group,complete improvement occurted only in 35.7%(5/14),partial improvement was seen in 42.9%(6/14) and ineffi-cacy remaind among the other 13.4%(3/14) of the patients.ConcIusion For patients with encapsulated tuberculous pleural effusion,regular antituberculosis treatment plus urokinase injection into the pleural cavity can increase the drain-age,decrease pleural thichening and improve pulmonary function of the patients.