The Research Of The Control Of Breathing Motion On Apply Of Simultaneous Integrated Boost Intensity Modulated Radiotherapy On Patients With Early Breast Cancer After Breast-Conserving Surgery

PurposeComparing simultaneous integrated boost intensity modulated radiotherapy with regular half tangent radiation applying on patients with early breast cancer after breast-conserving surgery, we confirmed IMRT can reduce the damage of lung and heart and not enhance the damage of skin. With active breathing control system, simultaneous integrated boost intensity modulated radiotherapy can further reduce the damage of heart and lung for patients of left breast cancer, so that it came true of protecting heart and lung much better. Materials and methodsThere were 30 patients with early breast cancer receiving radiotherapy after breast-conserving surgery, who were divided into 3 groups averagely. The first group accepted regular half tangent radiation, the second included patients with right breast cancer. We made SIB-IMRT planning and regular half tangent radiation planning by TPS separately. The third group was patients with left breast cancer, who acceptted radiotherapy with ABC. We made planning of regular half tangent radiation, SIB-IMRT at free breathing and SIB-IMRT at moderate deep inspiration breath hold separately. The prescribe dose of regular half tangent radiation was 2GyPurposeComparing simultaneous integrated boost intensity modulated radiotherapy with regular half tangent radiation applying on patients with early breast cancer after breast-conserving surgery, we confirmed IMRT can reduce the damage of lung and heart and not enhance the damage of skin. With active breathing control system, simultaneous integrated boost intensity modulated radiotherapy can further reduce the damage of heart and lung for patients of left breast cancer, so that it came true of protecting heart and lung much better.Materials and methodsThere were 30 patients with early breast cancer receiving radiotherapy after breast-conserving surgery, who were divided into 3 groups averagely. The first group accepted regular half tangent radiation, the second included patients with right breast cancer. We made SIB-IMRT planning and regular half tangent radiation planning by TPS separately. The third group was patients with left breast cancer, who acceptted radiotherapy with ABC. We made planning of regular half tangent radiation, SIB-IMRT at free breathing and SIB-IMRT at moderate deep inspiration breath hold separately. The prescribe dose of regular half tangent radiation was 2Gy4.18±3.26% (t=12.88, P<0.000) .6.In DVH diagram of left side breast cancer in SIB-IMRT group, V20 of single side was 17.70±3.98% at free breathing, 15.60±4.47% at mDIBH(t=8.33 , PO.000). V30 of single side lung wasl5.04±3.51% at free breathing, at mDIBH 13.2±3.88%,(t=7.71, P<0.000)= V20 of both sides lung was at free breathing7.59±2.15%, at mDIBH 6.75±2.15%(t=3.294,P=0.003)oV20 of heart volume was 5.49 ±3.60 at FB, at mDIBH 3.12 + 4.17% (t=8.473, PO.000) .V30 of heart volume was 4.18±3.26%, atmDIBHgroup2.13±3.52% O5.182, />=0.001)7.In DVH diagram , dose of mammilla was in SIB-IMRT group37.18±4.68 Gy, in regular half tangent radiation62.4+ 3.60 Gy (t=4.034, P=0.003) . ConclusionThe damage of lung> heart and mammilla were much more alleviated in patients with early breast cancer who accepted SIB-IMRT after breast-conserving surgery than regular half tangent radiation o If patients with left breast cancer used active breathing control system( mDIBH) during radiotherapy, the dose of heart absorbed can be more reduced. Thus, it was much better that those patients accept SIB-IMRT, that patients with left breast cancer use active breathing control can protect heart much more, and so it can alleviate the damage of lung and heart o...