Diagnostic Value Of Color Doppler Ultrasound In Bone Tumors

ObjectiveTo definite the extent of tumor invasion to soft tissue by real - time 2D - Ultrasound in bone tumors.To assess the value of Color Doppler Ultrasound in the vascularity of bone tumors.To analyze the diagnostic value of Color Doppler Ultrasound in bone tumors compared with histopathology.Materials and methodsPatients. From March,2005 to December 2005,49 patients were clinically suspected bone tumor in First Affiliated hospital of China Medical University (male 34,female 15,mean age 33 years old, range from 6 to 74 years old).Ultrasonography. The ultrasound investigations were performed using 5 ~ 12MHz transducer, (Philips ATL-HDI SONOCT 5000,Washington USA).The sites of the tumors were exposed fully and the lesions were scanned longitudinally and transversely in B mode , color mode and three - dimensional ultrasound mode. The location, the form, the size, the echo and the soft tissue a-round the lesion were observed. Data and images were saved in a computer system.Statistical analysis. The parameters of blood flow between benign and malignant bone tumors were compared by t - test. The degrees of blood flow among the bone tumors, 2D - Ultrasonography and invasion of soft tissue around the lesion were compared by Chi - square test. The correlations of 2D - Ultrasonogra-phy, invasion of soft tissue around the lesion, degree of blood flow, RI were analyzed by Pearson regression analysis.The above statistical analysis were conducted with the statistical software package SPSS for Windows, version 13.0.ResultsThere were 27 cases benign bone tumors, osteochondroma 10 cases, oste-oid osteoma 1 case, giant - cell tumor 2 cases, chondroma 1 case, non - ossifying fiberoma 6 cases, bone cyst 1 case, aneurysmal bone cyst 1 case, osteofibrous dysplasia 4 cases, giant cell tumor of tendon sheath 1 case.There were 22 cases malignant bone tumors, osteosarcoma 6 cases, chon-drosarcoma 1 case, Ewing sarcoma 2 cases, chordoma 1 case, malignant giant cell tumor 2 cases, metastatic tumor of bone 2 cases, malignant giant cell tumor of tendon sheath 1 case, fibular osteosarcoma 1 case, malignant bone tumors ( non — pathological -type)3 cases, malignant osteochondroma 1 case,malignant fibrous histiocytoma 1 case, rhabdomyosarcoma 1 case.1.2 CDFI^PCDE:According to half — quantitative method, the blood flow in the 49 cases of bone tumor were classified. The grades differed significantly between the benign and the malignant( P <0. 01 ). The dynamic analysis of blood flow in 8 cases benign bone tumors and 17 cases malignant ones showed PSV and MDV between the benign and the malignant did not differ significantly ( P >0.05) . However, RI differed significantly ( P < 0.01) .1.3 The results of Pearson regression analysis showed that the correlations of 2D - Ultrasonography, invasion of soft tissue around the lesion , degrees of blood flow ,RI were significant.1.4 For the bone tumors with Color Doppler Ultrasound, the sensitivity, specificity, accuracy, positive predictive value, negative predictive value were 90.9% ^88.9% ^89. 8% ^87.0% N92. 3% respectively.ConclusionUltrasonography is a valuable imaging method for diagnosing the bone tumors, especially for showing the invasion of soft tissue around the lesion.With the Color Doppler Ultrasound we can observe the blood flow in the lesion at real - time. The grades of the blood and the dynamic analysis play a role in distinguishing the benign from the malignant.3D -CDE may show the vascularity of bone tumors directly, real time and thoroughly.