The Relationships Among Leptin, Other Related Factors And The Motor Recovery Of Cerebral Infarction Patients

ObjectiveCerebral infarction is one of the most common and dangerous nervous system diseases, which has very high mutilation and fatality rate. Many survivors of cerebral infarction have motor disorder. In clinical practice, the results of motor recovery therapy are not sure because of the differences of condition of patients and therapy methods. Hypertension, diabetes, obesity or higher cholesterol may be risk factors of cerebral infarction. Leptin, a peptide hormone secreted by adipose tissue, have important roles in diabetes, hypertension and other cardiovascular diseases. Our aim was to examine the relationships among cerebral infarction and serum leptin level and other factors, to find factors associated with the motor recovery of cerebral infarction.MethodsThe general condition of patients such as sex, age, blood pressure, area of infarction, body mass index (BMI) and accompany disease of 103 patients of first - ever cerebral infarction were recorded. The biochemical markers including serum leptin, Fasting blood sugar (FBS) , total cholesterol (TC) , triglyceride (TG) , white biood cell (WBC) , high density lipoprotein cholesterol (HDL -C) and low density lipoprotein cholesterol ( LDL - C) were determined as soonas hospitalization. The emotion status and Fugl - Meyer motor scale (FMMS) before treatment were evaluated, and the FMMS on 21 days after treatment was evaluated again. The difference between before and after treatment was analyzed with student t test. The relationships of factors were analyzed with Pearson or Spearman correlation analysis. Multivariate regression was used to screen the most important factors relevant to motor recovery.ResultsAfter 21 days treatments, The FMMS of 103 patients was significantly better than that before treatment ( P < 0. 001) . The severity and rehabilitation efficacy of patients were significantly correlated with FMMS before treatment, area of infarction, serum leptin, FBS, diabetes, Depression and anxiety neurosis (P < 0. 05 ) . The serum leptin level was correlated with area of infarction, FMMS, diabetes, FBS and LDL -C (P < 0.001). The multivariate regression revealed that area of infarction (P < 0. 001) , leptin ( P = 0. 002) , FBS ( P = 0. 022) , diabetes (P = 0.001) , Depression (P = 0.006) and anxiety neurosis ( P =0. 023) were the six most important factors reflecting the severity of cerebral infarction.Conclusions1. Serum leptin level is significantly negatively correlated with FMMS, and is a useful marker reflecting the severity and motor recovery level of patients. 3. To prevent or treat cerebral infarction, it is very important to control FBS or diabetes and other accompany diseases. 4. Depression and anxiety neurosis have significant impact on the motor function, so the necessary psychotherapy will help the motor recovery of cerebral infarction patients.