Clinical Significance Of Pituitary Endocrine Changes After Moderate Hypothermia Treatment For Severe Diffuse Axonal Injury

Objective To elucidate the clinical significance of pituitary endocrine such as thyroid-stimulating hormone(TSH) , triiodothyronine (T₃) , thyrexine (T₄) , adrenocorticotropic hormone (ACTH) changes after moderate hypothermia treatment for acute severe diffuse axonal injury.Method Forty acute severe diffuse axonal injury patients (Glasgow coma scale smaller than eight points) that hospitalized within six hours after injury were divided into moderate hypothermia treatment group and normal temperature treatment group immediately. The serum TSH , T3, T4, ACTH were determined by chemiluminescence on the 1^st 3^rd, 5^th,7^th after injury. There are 10 normal persons'serum TSH, T3, T4, ACTH were determined to compare with those two groups patients'.Results After acute severe diffuse axonal injury, The serum TSH, T3, T4 in normal temperature group and moderate hypothermia group all decreased compared to the normal group(P<0.01),But the serum TSH, T3, T4 in normal temperature group decreased significantly than that in moderate hypothermia group (P<0.01). The serum ACTH in normal temperature group and moderate hypothermia group all increased compared to that in the normal group (P<0.01),The serum ACTH in normal temperature increased significantly than that in moderate hypothermia group (P<0.01). And those hormones in moderate hypothermia approached normal level earlier than that of normal temperature (P<0.01).Conclusion The findings indicate that moderate hypothermia treatment can reduce the changes of hormones significantly after acute severe diffuse axonal injury. Therefore, it can improve the prognosis and reduce the mortality of patients.