| Intrauterine growth retardation (IUGR) is also called the smallfor gestational age (SGA) too. It is the neonate that the birth weightunder 10% spaces at the average weight of the same pregnancy time.According to maturity degree, it can be divided into premature SGA,mature SGA and expired SGA. SGA have the complications not onlyrepresent the dwarfism of stature, but also accompany by wisdomobstacle and various deformities. Those may affect the normal growthdevelopment in the period after the fetus birth. The morbidity isabout 2.5%-7.5% at total neonate. About 20%-50% of IUGR have notthe chase of growth, their dwarfism of stature can keep on tochildhood period , and about 20% of their stature still bellows normalto adult period. Isulin-like growth factor-I (IGF-I) and insulin-likegrowth factor binding protein-3 (IGFBP-3) are closely related with thefoetal growth and development, IGF-I plays a major role in theregulation of the foetus's growth and developmental. Therefore, westudy 64 cases of neonatal, take vein blood specimens, and test thelevel of the IGF-I and IGFBP-3. Then we follow-up the IUGR, toexplore the relations of IGF-I,IGFBP-3 and human fetal developmentand catch up growth and its impact factor. It provide the theoreticalbase rationale and new idea for the IUGR early entervention. We collected 64 cases neonatal patients from December 2004 toFebruary 2006 in the first hospital of Jilin University. They weredivided into two groups: 1.Observer group: There were a total of 39cases in 321/7 to 41 weeks, of which 28 cases were mature neonates, 11cases were premature neonates.2. Control group: There were a total of25 cases in 34 to 403/7 weeks, of which 16 cases were mature neonates,9 cases were premature neonates. Mothers aged 18 -46 years. Theseven of 64 cases were twins, 22 cases of the mother accompanied bypregnancy hypertension, 17 cases were twisted the neck by umbilicalcord, and 10 cases had suffocation history. We Collected the birthhistory, birth weight, height and head circumference of all cases. Thenwe followed the IUGR at 6~12 month. At the time of borned 7daysafter birth and follow-up period, we collect 3 ml vein blood to test thelevel of IGF-I and IGFBP-3.The results showed that the level of observer group IGF-I andIGFBP-3 in observe group were obviously lower than control group.The difference was significant (P<0.05). The premature vein bloodIGF-I and IGFBP-3 were markedly lower than the mature (P<0.05).The serum IGF-I and IGFBP-3 were related with a birth weight,height and head circumference (P<0.01). IGFBP-3 was related withIGF-I, the movements of IGFBP-3 were consistent with IGF-I(P<0.01). Mothers are accompanied by pregnancy hypertensionsyndrome compared with those who didn't accompany by pregnancyhypertension syndrome, the former leve of serum IGF-I and IGFBP-3lower (P<0.05). The level of serum IGF-I and IGFBP-3 that twistedthe neck by umbilical cord or had suffocation history significantlywere less than the average non-twisted the neck by umbilical cord orhadn't suffocation history (P<0.05). Those had catch up growthcompared with those hadn' t, IGF-I and IGFBP-3 were lowed(P<0.01).So we got follow conclusions: 1.IGF-I and IGFBP-3 are relevantwith a birth weight, height and head circumference positively ,andthey are important factors to affect the intrauterine growth anddevelopment. 2. IGF-I and IGFBP-3 are relevant with pregnancy timepositively. 3. IGFBP-3 is relvant with IGF -I positively, themovements of IGFBP-3 are consistent with IGF-I. 4. It may be theimportant factor that Lack of oxygen/blood lead to IGF-I andIGFBP-3 lower. 5.The catch up growth is related with IGF-I andIGFBP-3.
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