| Background Cerebral Infarction is a kind of clinical common disease with high disabling rate and death rate, now have already become the important medical science subject for research. Pricking blood therapy for treatment of Cerebral Infarction was applicated by clinic acupuncturists at all times. However, it is still not deep enough that relevant clinical mechanism are studied. The domestic mechanism that treated Cerebral Infarction to acupuncture has carried on the discussion in recent years. It is thought that acupuncture has influence in various degree on such respects as blood rheology , brain blood flow picture , electroencephalogram(EEC) , little circulation , serum fat quality supersession and immune system ,etc. The purpose of this study is to observe the therapeutic effects of Plasma Endothelin (ET) contents and blood coagulative system by pricking blood therapy and to observe curative effect of pricking blood therapy on treatment of Cerebral Infarction.Objective (1) To observe the therapeutic effects of pricking blood therapy at Point Erjian for treatment of Cerebral Infarction. (2) To observe the therapeutic effects of Plasma Endothelin (ET) contents which were determined before and after treatment. (3) To observe the therapeutic effects of blood coagulative system which were determined before and after treatment, concluding prothrombin time( PT ),activated partial thromboplastin time( APTT ) and Fibrinogen( Fib). (4) Toexplore the mechanism and clinical value of pricking blood therapy for trentment of Cerebral Infarction.Methods1.Patients enrollment: Choose the patients according to " all kinds of main points of medical diagnosis on disease of blood vessel of brain " that Chinese dept. of neurology learn to be announced in 1996, and studied CT or MRI by the image to verify for the patient which is short of courageous and upright apoplexy;Chinese medicine diagnostic standard choose 1996 " apoplexy disease diagnose according to China traditional Chinese medicine with the criteria for evaluation of curative effect". Adopt patients are divided to bloodletting treat group and routine Western medicine contrast group.(2)Exclusion criteria: ?Patients who the physique is extremely weak, or serious anaemia and low blood pressure person;?Patients who with infectious disease;? Patients who with serious damages function of heart, liver , kidney and blood disease patient;?Person who amalgamates cerebral hemorrhage;?Patients who over 75 years old;?Patients who beyond the criteria, who couldn't take medicine in accordance with requirement, who hasn't complete data. 40 patients were enrolled. 24 man, 16 women, mean age (64. 73 + 7. 64) years old.2. Treatment method: Control group: The patients were treated with the routine medicine, the high pressure in the cranium persons use dehydrates in early days, 20% mannitol 125ml dripped for 3-5 days;with expanding the blood vessel medicine , anticoagulatory medicine. Therapy group:Operation: ?Find erjian point of the patient, and disinfect around the point with 75% alcohol;?Prick the point about 5mm depth;?Extrude the point with both hands, then clean the blood with sterilized tampon till the blood is about 5ml. Treat once a day , seven days as one period of treatment. The patient must take a good rest, avoid being overtired , keep spirit happy during the treatment period.3. History investigation and physical examination: Patients were investigated andrecorded the case history of CAD, EH, hypercholesterolemia, diabetes mellitus, renal disease, cerebral stroke and family history. The body height, weight, heart rate and blood pressure were recorded and systemic physical examination was performed.4. Lab examination: The serial level of liver function, renal function, Plasma Endothelin (ET), prothrombin time (PT), activated partial thromboplastin time(APTT), fibrinogen(FIB), were measured within 24 hours before treated and 2 weeks when the study would be finished.5. Chinese Medicine features examination: The changes of clinical features and signs include tongue, pulse were written down within 24 hours before treated and 4 weeks when the study would be finished.6. Follow up: Control group and therapy group have followed up for 1 month.7. Statistic analysis: T test, x2 test, Raddit analysis were selected. Results1. Discontinuation and baseline clinical characters: 11 patients discontinued and the rate of discontinuation'was 21.57 percent. Each group includes 20 patients. The sex, age, course of disease and complication were similar.2. Effects of pricking blood therapy at Point Erjian for treatment of Cerebral Infarction: both groups could obviously improve clinical symptoms in the patients of Cerebral Infarction (PO.01) . Comparing with control group, therapy group were more obviously(p<0.05).3. Effects of pricking blood therapy on the level of Plasma Endothelin (ET): ET in both groups were decreased, comparing with control group, changes of ET in therapy group were more obviously (PO.01).4. Effects of pricking blood therapy on the level of blood coagulative system: PT and APTT in both groups were shorten , the level of FIB in both groups were increased, changes were similar before trentment. After trentment, PT and APTT in therapy group were lengthen , the level of FIB were decreased, comparing with control group, changes of PT, APTT and FIB in therapy group were moreobviously (P<0.05).5. The curative effects and clinical value of pricking blood therapy on patients with CI: integral calculus was decreased and Traditional Chinese Medicine syndromes were improved in both groups. Comparing with control group, changes in therapy group were more obviously.Conclusion (1) Pricking blood therapy at Point Erjian could improve clinical symptoms in the patients of CI .(2) Pricking blood therapy at Point Erjian could decrease the level of ET in Cerebral Infarction patients;(3) Pricking blood therapy at Point Erjian could decrease the level of FIB and lengthen the time of PT and APTT in CI patients;(4) The combined treatment (including pricking blood therapy and routine medicine) of CI was superior to the routine medicine.
|
PDF Full Text Request