The Correlation Between Serum Phospholipids Fatty Acids And Blood Lipids In Hypertension

The hypertension and obesity have been dramatically increasing in China. Association between diet fatty acids and the development of non-communicable diseases such as hypertension, obesity, diabetes mellitus etc. are increasing interesting in medical literature. Total fat and fatty acid composition in the diet play an important role in above diseases. However most of the fatty acids profile in previous studies were limited on free fatty acid .Objective: To investigate serum phospholipid fatty acids (biomarker of fatty acid intake) profile in hypertension patients, obesity-related hypertension patients, obesity patients and healthy control groups, and the relationship between plasma lipoprotein lipids and phospholipid fatty acids.Methods: A case-control study, 44 hypertension patients and 41 obesity-related hypertension patients and 43 obesity patients and 53 healthy controls were participated in the study. Serum phospholipid fatty acid was analyzed with capillary gas chromatography. Plasma lipids were measured by enzymatic assay.Results:1. The composition of total n-6PUFA and total SFA were significantly higher in hypertension group and obesity-related hypertension group than in healthy controlgroup, while total MUFA, n-3 PUFA and ratio of n-3/n-6PUFA were significantly lower than in healthy control group. Total n-3PUFA was significantly lower in obesity-related hypertension group than in hypertension group. C18:2n-6 was significantly higher in obesity-related hypertension group than in obesity group, while C20:0 and C20:5n-3 were significantly lower than in obesity group.2. Compared with healthy control group serum lipid index such as TC, TG, and LDL-C were significantly higher in hypertension group and obesity-related hypertension and obesity group than in healthy control group, while HDL-C was significantly lower than in healthy control group.3. Bivariate correlation analysis showed that TC was positively correlated with C14:0, and negatively correlated with C18:l and C20:4n-6;TG was significantly negatively correlated with C20:4n-6 and n-3/n-6PUFA;LDL-C was positively correlated with C18:0 and negatively correlated with C20:5n-3 and n-3PUFA. HDL-C was positively with C16:l > C18:2n-6 and C22:6n-3 and negatively correlated with C16:0.Conclusion:1. Serum phospholipid fatty acids profile was different between hypertension group and healthy control group. Serum phospholipid total SFA and total n-6PUFA were higher in hypertension group than in healthy control group, total MUFA, total n-3 PUFA, and ratio of n-3/n-6PUFA were significantly lower than in healthy control group.2. There is significant difference among hypertension and obesity-related hypertension and obesity group. Serum phospholipid total n-3PUFA was lower in obesity-related hypertension group than in hypertension group. C18:2n-6 was higher in obesity-related group than in obesity group, C20:0 and C20:5n-3 were significantly lower than in obesity group.3. The present results showed that the dietary SFA intake may contribute toblood lipid metabolism system, and MUFA and PUFA intake may have a protective effect.