Three Cases About Acyclovir Induced ARF

Objective To investigate the clinical characteristics of Acyclovir-induced acute renal failure(ARF).Methods Three cases with Acyclovir induced ARF were reported retrospectively and the related literature were reviewed.Results (1) ARF was untypical, just 1 patient experienced oliguria, 2 patients accompanied significantly flank or abdominal pains, but two patients represented proteinuria and microhematuria. ARF developed within 24 hours of acyclovir administration (2) We performed renal ECT on two cases and found c stage showed significantly excretion retarded. The renal biopsy of one patient showed expanded tubular, swelling interstitial and some crystalline lens in tubular, without the involvement of glomerli. (3) All cases recovered completely with discontinuation of acyclovir therapy and volume resuscitation in 3-11 days.Conclusion Intratubular crystal deposition and tubular obstruction was the main mechanism of Acyclovir-induced ARF. Flank or abdominal pains is its significant symptom. All cases recovered soon and normative usage of acyclovir is the key to prevent ARF occurred.