The Correlation Of Mild Renal Dysfunction On Severity Of Coronary Disease

Abstract: Background Cardiovascular disease (including coronary heart disease) is the NO.1 cause of death in patients with end-stage renal disease.Morever,higher rates of Cardiovascular disease (CVD )are seen in patients with moderate and even mild renal dysfunction, particularly if the patient has hypertension or diabets.Recent studies have indicated that even modest elevations in serum creatinine and urinary albumin are associated with increased CVD risk,not only in persons with diabets or hypertension but also in the general population.Renal dysfunction is intensively associated with CVD (including coronary heart disease).the mechanism between them is still determining.Objection: study and contrast the difference on severity of coronay disease between the patients of normal renal function and mild renal dysfunction who have coronary heart disease,to analysis thecorrelation of renal dysfunction on severity of coronary disease.Method: Twenty eight patients with 2. 2 mg/dl ^ serum creatinine ^ 1.2mg/dl who have coronay heart disease(study group).Thirty patients with creatinine<1.2mg/dl who have coronary heart disease(contrast group).measure serum creatinine> uric acid^ fbs >Tc , Ldl-c and patient was admitted.Then observe and estimate the severity of coronary disease when carry out coronary angiogrphy.Analysis the correlation of renal function on severity of coronary disease.Result: the severity of coronary stenosis significantly increased in mild renal dysfunction group compared with normal renal function group.In addition,both Tc and smoking are associated with the severity of coronary disease.Conclusion:mild renal dysfunction is positively associated with the severity of coronary disease.