Clinical Observation Of Induction With Different Doses Of Sufentanil And Propofol

Objective: Through observing changes of bispectral index(BIS)and hemodynamic response during induction and intubation with different doses of sufentanil and propofol, we sought to determine the optimal doses of sufentanil and propofol for induction and intubation.Methods: Forty ASA I ~ II patients undergoing elective radical operation for breast cancer, who were randomly allocated into four groups(ten cases each group): group I was injected normal saline as contrast;group II, III and IV were intravenously administered sufentanil 0.2μg/kg, 0.4μg/kg and 0.6μg/kg respectively. Intubation was performed following maintenance of BIS at the level of 45 ± 5 for 3min. ECG and cardiovascular variables were recorded at pre-induction, pre-intubation and post-intubation.Results: In group I and II, post-intubation blood pressure and heart rate were significantly changed compared with pre-intubation (P<0. 05) , but no significant changes in group III and group IV. In group I , II and III BIS was increased to 53. 5±0. 8, 54. 4±0. 7 and 49. 1 ±0.6 respectively, while in group IV, no significant increase of BIS was noteced.Conclusions: Sufentanil 0. 4μg/kg or more can effectively blunt the hemodynamic response to intubation, but only 0. 6 μg/kg sufentanil attenuates the arousal of cerebral activity.