| The researching field of surfactants is an important project area, such as biology, clinical medicine, foodstuff, petroleum and so on. Especially in the field of medicine, they can be used as disintegrating agents, diluents, suspending agents, emulsifying agents, and solubilizing agents. Surfactants such as SDS and Tweens have been widely utilized as an approach to increase the water solubility of many pharmaceutical substances that represents a formidable problem in formulation of an acceptable dosage form. In this thesis, the author used the six new synthesized surfactantsofN-dodecyl-hydroxyl-dimethyl ammonium bromide, N-tetradecyl- hydroxyl-dimethyl ammonium bromide, N-cetyl-hydroxyethyl-dimethyl ammonium bromide, N-dodecyl-dihydroxyl-methyl ammonium bromide, N-tetradecyl- dihydroxyl-methyl ammonium bromide, N-cetyl-dihydroxyethyl-methyl ammonium bromide and Norfloxacin as research objects. The author applied the technologies of spectroscopy and studied the interaction mechanisms between the six surfactants and Norfloxacin.In the part of spectroscopy analysis, the interaction of surfactants andNorfloxacin has been investigated by using the fluorescence spectroscopy and UV-Vismeasurements. The equilibrium constants and number of binding sites for Norfloxacin in this researching with surfactants are measured by Benesi-Hildebrand Equation and Scatchard Equation. The spectroscopy analysis shows that all these surfactants can react with Norfloxacin and form a drug-surfactant compound. Furthermore, all of those surfactant can affect the configuration of the one Norfloxacin.Considering the hydrophobic, association and steric function,it conclude that the strength of interaction of Norfloxacin with surfactants order is N-cetyl-dihydroxyl-methylammoniumbromide>N-cetyl-hydroxyl-dimethylammoniumbrornide>N-tetrade cyl-dihydroxyl-methylammoniumbromide>N-dodecyl-dihydroxyl-methylammoniumb romide>N-tetradecyl-hydroxyl-dimethylammomumbromide>N-dodecyl-hydroxyl-di methyl ammonium bromide. |
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