Estrogen And Its Receptors Impact On Liver Metastasis Cancer From Colorectal Carcinoma

Background Several papers have proposed that high incidence of metastatic liver carcinoma from colorectal carcinoma ,when diagnosed as CRC(Colorectal Cancer) , reached 20% to 40%, and metastatic liver cancer should response to the high mortality. A large scale case investigation indicated us that there were difference between the male and female in incidence of metastatic liver cancer, and the ratio of incidence between genders was 1.9:1. There were also some documents reported postmenopausal women would decrease the risk for CRC if intaked some certain dose estrogen, but if CRC women kept on intaking estrogen, it would lead to CRC up-staged and increase the possibility of metastasis. Because of the introduction of new subtype estrogen receptor—ERβ, people recognized ERβas the overwhelming abundant ER in CRC tissue gradually. ERβcorrelated with cell proliferation and expression of adhering molecule, and high ERβexpression inhibited the cell proliferation and increased adhering molecule level,such asα-catenin. Taken together, we thought estrogen and ER may correlated with CRC metastatic liver cancer.Objective We assay the ERβexpression status in metastatic liver cancer tissues,and serum estrogen level in metastatic liver cancer patients in order to evaluate whether E/ER are the impact factors of CRC metastatic liver cancer.Method Immunohistochemical stainning with antibody to ERαand ERβwas perform on histologic sections, whose samples derived from metastatic liver cancer, colorectal cancer mucous, normal mucous distant from cancer tissue and prepared from paraffin block. We use E2 RIA Kit to test metastatic liver cancer...