| Rheumatoid Arthritis (RA) is a sort of chronic , inflammational , systemal disease of self-immunity , with mainly clinic characterizes as local-arthritis pain , terminal result can be ankylosis monstrosity and even function invalidate with joints . This disease is ubiquity all aroud the world , have the characterizes such as : long course of disease , diffcult to cure totally , have high cripple rate and hard to reoccur . Threaten human health and live quality severity , So the treatment of this disease is a problem that many professors work hard on and also a problem that is very difficult to solve .The reason and the mechanism of the disease are not very clear yet , and all the opinions that were put out can only explain part of the symptoms . But more and more professors have the same opinion that the disorder of the immune system has close relations with the disease . Many researches have already been indicated that lymphocyte , neuter- granulocyte , macrophage cell , slide-checa cell etc. multi-inflammational cells lead to abnormal cellularital immunity and body-fluid immunity , finally make for immunity dysfunction of part- arthrosis and systemic , its plays an importance role in course of pathology of RA .Wutou Decoction is a famous prescription created by a famous doctor named Zhang Zhongjing in Dong Han age , this prescription is comprised by Aconite , Astragalus , Ephedra , Peony and Roast-liquorice , have the efficacy of warm venation so that dispel cold , drive away damp and alleviate pain , it can mainly treat arthralgia syndromes caused by cold and damp . According to previously clinical experiences and animal experiments of these years , it proved that this prescription has doubtless cure function on anti- rheumatoid arthritis . it has a certain extent of ease pain , has the function of anti-acute or chronic inflammation , especially for acute inflammation . The study about Wutou Decoction on prescription rules and further animal experiment are very poor , this study observed pharmacology target such as cytokine , hemorrheology , T-lymphocyte clusters and immunity organ . So one hand we can reveal the compatible rules of Wutou Decoction , demonstration the existed theory , on the other hand the reacher can provide for modification of prescription , improve the original prescription and create more effective prescription . The result of this experiments indicate that :1 The effects of cytokine content in AA-rats' blood serum : Wutou Decoction group and its prescription groups can reduce the cytokine (IL—1 ., TNF— a)content in AA-rats' blood serum , the drug effect is especially good in Wutou Decoction group , the different compared with model group has a remarkable significance . It indicate that Wutou Decoction group and its prescription groups can prevent slide-checa fibroblast excess multiplication on differ degrees , so they can exert immune adjust function on network level of cytokine , in this way , achieving the aim that anti- rheumatoid arthritis .2, The changes in hemorrheology of AA-rats : Compared with model group , the influence of traditional Chinese medicine treaty on hemodynamics embody in many aspects of Wutou Decoction group and its prescription groups . On the one hand, it is able to reduce the hematocrit and plasma viscidity notably , On the other hand , it can reduce the the index of red blood corpuscles togather,thus demonstrate the whole blood viscidity and whole blood reduce viscidity to drop . Indicate that Wutou Decoction can reduce blood high-curdle and high-thick , remove blood stasis , improve and resume tiny-circulation , increase body nutrition , lighten system trauma , so that play anti- rheumatoid arthritis function .3^ T-lymphocyte clusters (CD4+ and CD8+) content in AA-rats blood measure result indicates : In model group , the percent of CD4+ in AA-rats blood is evidencely increased , the percent content of CD8+ cell is reduce , at the same time , the rates between CD4+ and CD8+ have the trend of increase . Wutou Decoction group and its prescription groups can play differ effects on T-lymphocyte clusters (CD4+ , CD8+ and CD4+/CD8+) , as a result , restrain the over-excited cellularital immunity .4s From the immunity organ aspect , we can see in the course of anatomise ,with naked eye , Thymus gland and spleen of model group rats have differ degree hyperemia , and even in some rats , there spleen tumescence and thymus gland atrophy are very seriously . After therapyed with Wutou Decoction group and its prescription groups , the damage in immunity organ can be lighted in differ degrees , so we can confer , Wutou Decoction can resume the immunity function , anti- rheumatoid arthritis from fundamentality .5> About this prescription rules : Wutou Decoction group and its prescription groups all can manifest different degree function of anti-inflammation , adjust immunity, activating blood flow . But on the whole , the curative effects of prescription groups are less than Wutou Decoction group . Compare to Wutou Decoction group , there are no obvious difference . It not only shows the rationality of forming prescription of Wutou Decoction , but also the correctness of prescription compatibility theory . There are no obvious differences between Wutou Decoction group and prescription groups , the mostly causes may be : Firstly, modern pharmacology researches show , each herbal medicines in perscription have definite function of anti-inflammation and analgesis , moreover , Astragalus has bidirection of adjust immunity function . All these may be one reason of cause no obvious different between Wutou Decoction group and its prescription groups . Secondly , it also may be we made animal model does not according to the theory of Traditional Chinese Medicine . As the theory of TCM , Wutou Decoction has the function of treat arthralgia syndromes caused by cold and damp , it arises relate to outside environment and depressed body immunity function . But our study is a disease model of modern medicine , it does not aim at pathogeny and pathology of TCM . But each prescription group has a certain extent effect , it also show that every herble medicine has take part in the whole function , the result is the reciprocity of all herble medicines cooperate with each other together.Synthesizing the former results , Wutou Decoction have good effect of anti-rheumatoid arthritis , its function mechanism is a multi-approaches and multi-points synthetical-effect result . This study is just a begin , we hope more researches appear with further level . |
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