An Analysis Of Multiple Correlation Factors With Post-stroke Depression

Purpose To study the prevalence and multiple correlation factors of post-stroke depression in stroke acute phase . We expect providing some help of early diagnosis and treatment of post-stroke depression.Methods Case-control study was used. The patients were from the Neurology Department of No. 2 the people's hospital of Taiyuan during June 2004 to February 2006 .They were all inpatients of new-onset stroke and standards-compliant .When patients admitted, we inquired there medical records in full, include the history of coronary heart disease, diabetes, hypertension, hyperlipemia and other diseases. Clinical examination, blood glucose detection, blood fat detection, fibrinogen detection, blood pressure examination, ECG examination, neuroradiological CT or MRI scan examination , social support assessment, life event assessment were performed just after the patients admitted. In the fourth week after the stroke onset, Psychiatric assessment and neurologic assessment were performent. Depression was screeninged with Self-Rating Depression Scale(SDS).If SDS score≥32,we use Hamilton Depression Rating Scale for Depression(HRSD) to determine depressed patients. If the patients'HRSD score≥8 and consistented with the diagnostic criteria of depression in CCMD-3 of Chinese, they could be diagnosed PSD. The PSD patients were classified as case group,and the others were control group.Results Total 101 patients were investigated . But in the end 88 patients fufiled all investigations. In the 88 patients, there were 56 males and 32 females and 42-78 years old. The average age was 62.8±7.5. The frequency of any depressive disorder was 37.5%(n=33). Major depression was diagnosed in 9.09% (n=3) and minor depression in 42.42% (n=14). We found no statistically significant difference in sex, age, stroke type, stroke localization, focus numbers, Risk factors of cerebrovascular disease(coronary heart disease, hypertension, diabetes, hyperlipemia, high fibrinogen), occupation, habitation, culture degree, income, and life events. According to the multiple logistic regression model, dependency in daily life ,the extent of neurologic impairment and social support correlated with the diagnosis of depression (odds ratio [OR], 0.782, 1.5, 0.513 respective ; 95% confidence interval [CI], 0.638 to 0.957, 1.048 to 2.147, 0.304 to 0.866 respective).Conclusions Clinically significant depression is frequent after stroke. We emphasize the importance of the psychiatric examination of poststroke patients, especially those with a significant disability and being scarce of social support.