Effects Of Atorvastatin On Expression Of TNF-α And INOS In Experiment Allergic Encephalomyelitis

Objective: Multiple sclerosis (MS) is an inflammatory demyelination disease of the central nervous system that causes relapsing and progressive neurological impairment. The disease-modifying agents currently used in the treatment of MS are not completely effective and are associated with adverse effects and high costs. Thus, alternative treatment options are highly desirable.HMG-CoA reductase inhibitors"statin"are widely used oral cholesterol-lowing drugs. Apart from the effect of lowing cholesterol, statins have important biologic effects that may be independent of their cholesterol-reducing properties. Recent studies indicate that statins have anti-inflammatory and neuroprotective properties which may be a future treatment option for MS-either in an add-on therapy regimen or alone.In our study, we administrate atorvastatin to the rats of experiment allergic encephalomyelitis (EAE)-an animal model of MS, in order to investigate the therapeutic potential in treatment of neuroinflammatory diseases like MS.Methods: One hundred healthy female Wistar rats weighing 180-200g were divided into four groups: blank control...