The Protective Effects Of Myocardium Ischemic Preconditioning On Renal In Pigs With Open-heart Surgery

Recently, systemic inflammatory response syndrome (SIRS) induced by cardiopulmonary bypass(CPB)had been considered as an important mechanism in which acute renal injury associated with CPB devoloped. The effective treatment and prevention should be based on the complete comprehension of the SIRS. Many documents had published to explain the mechanisms of SIRS revulsived by CPB, but some complicated mechanisms were not yet clear. There were many pathological changes in SIRS, including the solution of the fibrinogen, the activation of the addiment, the release of the endotoxin, the activation of the leukocyte and the plastocyte and the release of the cytokines. It should be paid more attention to that the activation of each cytokine and system was not independent, but a complicated interaction.Since Murry and his colleagues introduced the concept of ischemic preconditioning (IPC) the first time in 1986, IPC had become a new way in which the tissue and organs were protected. It worked through increasing the endogenous ability against ischemic reperfusion injury. Through the extensive research on IPC, people had found its protective effects not only...