The Renoprotective Role Of Rosiglitazone In Rat Model Of Type 2 Diabetes Mellitus

Objective: Diabetic nephropathy (DN) is one of the major microvascular complications of type 2 diabetes mellitus . Basement-membrane thickening and mesangial expansion have long been recognized as pathological hallmark of DN.Type â…£ collagen (Col-â…£) is the main component of the normal glomerular basement membrane and play a pivotal role in the process of DN.Rosiglitazone belongs to thiazolidinediones (TZDs)which is a kind of novel insulin sensitizer.TZDs are believed to work through binding and modulating the activity of a family of nuclear transcription factors termed peroxisome proliferator-activated receptor γ (PPAR γ ). It is associated with slow improvement in glycemic control in parallel with an improvement in insulin sensitivity and reduction of FFA levels. TZDs have renoprotective function which is independent of insulin/glucose effects. Recently, numerous reports showed that TZDs could inhibit cell proliferation via cell cycle arrest in G₀/G₁ phase in varieties of cell types including vascular smooth muscule cells, cardiac fibroblasts and tumor cells in vitro. Whether TZDs have the same action on malignant cells induced by high glucose are still unclear. What is more, the molecular...