Study Of Association Between The Polymorphisms Of P21 And P27 Gene And Non-small Cell Lung Carcinoma

Objective: The occurring of tumor is due to general effect of individual heritability and environmental factors. P21 gene and p27 gene are two members of the cip/kip family of cyclin-dependent kinase inhibitors and connect with cell cycle control. They delay the cell cycle in normal. This effect will decline when the two genes express abnormally, which may induce cells grow actively, and develop a tumor eventually. P21 gene and p27 gene were regarded as candidates of tumor suppressive gene. There are several common polymorphisms described in p21 gene as well as p27 gene and these polymorphisms may alter the level of gene transformation and protein expression, so as to change the human genetic susceptibility of tumor. This study was to investigate the correlation of the single nucleotide polymorphism (SNP), a C to T transition at the 20bp 3'-untranslated region (3'UTR) of p21 gene exon 3 and a T to G transition causes an amino acid substitution of glycine for valine at the 109th codon of p27 gene (V109G) for association with genetic susceptibility and lymph node metastasis of non-small cell lung carcinoma (NSCLC) in a North China population.Methods: This study was divided into two groups. Two...