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Effect On Cardiomuscular Structural Remodeling For Spontaneously Hypertensive Rats Treated With Huaimijiangyakeli

Posted on:2007-06-13Degree:MasterType:Thesis
Country:ChinaCandidate:M X HuFull Text:PDF
GTID:2144360185452902Subject:Diagnostics of Chinese Medicine
Abstract/Summary:PDF Full Text Request
Objective: To prove the curative effect of Huaimijiangyakeli and further for the functional mechanism on preventing cardiomuscular structural remodeling of spontaneously hypertensive rats and preserving heart function through the animal experiment.Methods:Part 1: The Pharmacology research of Huaimijiangyakeli and effect of Huaimijiangyakeli on Pathological morphology of spontaneously hypertensive rats1. The effect of Huaimijiangyakeli on hypertension of spontaneously hypertensive ratsIn order to adapt to the environment, the rats were feed in the clean laboratory for experimental animals for one week, where the temperature was at 18-22℃and the day and night was each for 12 hours. 36 spontaneously hypertensive rats(SHR),male, were randomly divided into 4 groups,9 rats every group, namely①model control group(called model group), 1ml/100g steam water were given through the means of watering stomach;②model+ low-dose group of Huaimijiangyakeli (called low-dose group),...
Keywords/Search Tags:Huaimijiangyakeli, cardiomuscular structural remodeling, spontaneously hypertensive rats, endothelins-1, calcitonin gene-related peptide, angiotensinâ…¡, aldosterone, apoptosis
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