| Hypertension left ventricular hypertrophy ( LVH) is one of the major risk factors, leading to cardiovascular disease death. LVH represents the key path of development from hypertension to congestive heart failure and death. There are sufficient evidence to illustrate that LVH is the main risk factor and prognosis signal of inducing stroke, myocardial infarction, sudden death, diaphragmatic angina, congestive cardiac failure and kidney failure. Thus, seeking for ideal drugs, which have a good curative effect, less side effect, higher safety, and could step down the blood pressure and reverse LVH, is an important subject for studying hypertension, also an interesting question. Pathogenesy of hypertension LVH is extremely complicated, referring to many pathological and physiological mechanism. It has been confirmed that angiotonin II 1 receptor (AT1R) plays a very important role in multiple factors. Angiotonin II (Ang II) is the primal active compound, meditating almost all physiological effect.This topic, using the research of LVH model of G-RHR with kidney substance hypertension , discuss its blood pressure and LVM and bulk of myocardium cell and high express of c-fos , c-myc .As you know , by using the Chinese traditional medicine personly, the topic make a conclusion to the treatment function of XinShuKang .The result of the experiment research manifests: â‘ XinShu Kang have a satisfactory function of declinging blood pressure;â‘¡XinShuKang is able to decrease LVMI, bulk of heart cell and constrain fibre of indirect cell. â‘¢By observing the electronic mirror and light mirror and immunity chemistry confirm: XinShuKang is able to constrain high express of cardiac muscle AT1R. Therefore, it also can alleviates and diverse the functionofLVH. |
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