Analysis Of Relationship Between Polymorphism Of HLA-DRB1/DQB1 Alleles And Longevity

Objective:Human Leukocytes Antigens (HLA), located on the short branch of 6th pair of chromosome, is a gene cluster interlocking each other closely, i.e., 6P2 .1 .3. Its full length is about 3500kb and is known as the richest polymorphism of genes system so far. The amount of information HLA holds accounts for 1‰of the total information human has. Conventionally, HAL is grouped into Type I (HLA-A,B, C etc.), Type II (HLA-DR, DQ, DP, etc.) and Type III (C2, C4, etc., complementary genes). They are separately coded into three different kinds of HLA antigen molecules, which are specially characterized in their outcome structure, standout mode, tissue layout and function. Among these three types, Type II is located in Zone D, belonging to immunologic function related genes, playing very important role in immune response. Due to the significance of HLA in immunologic regulation, foreign researchers pay lots of attention to the research of the interrelationship of HLA with longevity. Many researches have shown, there is a direct relation between longevity and immune system function, saying genetic factor that determines the life limit may exist on some of the genes that control immune functioning, particularly HLA-Type II gene. Therefore, most researchers stress their focus on investigating the HLA-Type II genes. And many related research findings have been reported. But, since that ethnicity, nationality, region of humankind and angle of research are various, the conclusions differ a lot, even some are totally opposite, which is just the...