Cloning, Prokaryotic Expression Of Mycobacterium Tuberculosis Rv2389c And Rv2450c Genes And Preliminary Investigation Of Their Biological Functions

Tuberculosis(TB) is a chronic respiratory infectious disease caused by pathogen Mycobacterium tuberculosis(MTB). It severely threats the public health and kills more people in the world than any other single bacterial infection. Following the increasing incidence of AIDS, the incidence and mortality of TB are increasing rapidly in many countries and districts. In the past 10 years, TB is the main cause of people's death. It is estimated that one-third of the world population are infected with MTB and most of them harbor a persistent (latent) infection. There appear about 8 millions people get sick with TB and the number of death is about 2 millions annually. From 2002 to 2020, if the infection with MTB could not be controlled effectively, there would be another 1 billion people infected with MTB. The number of TB patients of our country rank the second place of all over the world. China is one of the 22 countris with high incidence of TB. This is due to the TB multidrug-resistant strains, co-infection with HIV and the increasing mobility of population. About 90% TB patients are dormantly infected by MTB. So we should deeply research on TB pathogenesis to find more effective new techniques, new methods and new vaccine for detection, treatment, as well as protection against mycobacterial infection.