Electrolytic Lesions Of Ventral Subiculum Prevent The Morphing Induced Conditioned Place Preference In The Addicted Rats

Objective Addiction is a chronic and recrudescebal brain disorder with psychosocial and neurobiological determinants, the main behave is compulsive drug use-loss of control over apparently voluntary acts of drug seeking and drug taking. The relaps is the mainly characteristic and the leading problem of drug addiction. The reinstatement factor includes three as below: â‘ drug priming â‘¡stress â‘¢drug-associated cues. Previously reaserch suggest that when the drug was taken, the VTA-DA neurons which projected to the NAc are excited, and the DA release into the NAc, which cause the NAc-DA level to increase in a high level. And the increase of DA level means a reward effect, it is a delightful feeling, it can be facilitated to take the drug by this feeling. Another reason is the physical dependence, it is many of discomfort feelings, but it could disappeare after stop useing the drug. So the physical dependence is not the mainly reason in relaps, but is the psychological dependence. The craving for drug is mainly wakening by drug- associated cues. Recently study showed that stimulation of ventral subiculum of the rat which had withdrawn from an addiction can trigger drug craving. The...