The Research On The Expression Of HIF-1 α And Its Relationship With Apoptosis And Proliferation In Esophageal Carcinoma EC9706 Cell Line

Background and objective:Hypoxia inducible factor-1(HIF-1) is a kind of transcription factor mediating hypoxic adaptation, which lies in mammals and human cells. Research indicates that it widely lies in many kinds of human tumor cells, which is a key protein that directly reacts to the oxygen deficit. HIF-1 is a heterodimer comprising HIF-1α and HIF-1β subunits, both of which are basic helix-loop-helix transcription factors. HIF-1 a is the only sub-unit of oxygen regulation, which can decide the activity of HIF-1. Its activity plays important roles in maintaining the energy metabolism of tumor cells, in the new angiogenesis and in promoting the tumor's multiplication, invasion and metastasis. HIF-1 activity in tumors depends on the availability of the HIF-1 alpha subunit, the levels of which increase under hypoxic conditions and through the activation of oncogenes and/or inactivation of tumor suppressor genes. Hypoxia is a common characteristic of solid tumors that has been associated with diminished therapeutic response and with malignant progression. The overexpression of HIF-1 a protein lies in many kinds of malignant tumors, which closely related to the poor prognosis. Some studies show that antiapoptotic proteins, such as Bcl-2, can be induced, whereas the proapoptotic protein Bax can be down-regulated during hypoxia. There is an intricate...