| Background: T-2 toxin belongs to A subgroup of Tricothecenes and is one of the most toxic toxins in such compounds, generated mainly from such molds as F.tricinctum, F.poae, F.sporotricoides, F.equiseti and so on. T-2 toxin mainly pollutes agricultural products such as wheat, maize, barley, oat, rye and also malt, beer and bread. Reports on T-2 toxin pollution mostly concentrates in the investigation on grain and feed.And it can be checked out not only in wheat and maize in domestic Kaschin-Beck disease infected area, but also in wheat and rice of noninfectious area of domestic Kaschin-Beck disease. Combined with foreign and domestic data, T-2 toxin has a certain degree of pollution for different cereals in different parts of the world.In animal experiments, T-2 toxin on animals shows a clearer immunotoxic and blood toxicity, suppresses DNA, RNA and protein synthesis, induces cell to die and causes leucocyte lack and so on. If people eat cereals polluted by such toxins, can result in besides acute symptoms of vomiting, abdominal pain, diarrhoea, can affect lack of leucocyte, angina gangraenosa, osteomyelodysplasia, severe necrosis of esophagus and stomach, pyohemia and so on, lethal rate is very high (mortality rates as high as 50%-60%). During World War II in the former Siberian Amur region, thousands of people had food intoxication due to consumption of winter wheat polluted fusarium and T-2 toxin was found high-level in the subsequent tests. Flood in Anhui and Henan provinces caused wheat mold in 1991. 47 of 48 samples collected were polluted by T-2 toxin and the average content is between 255.9-671.6ppb and the highest value to 1064.6ppb. Furthermore, T-2 toxin is closely related with the high... |
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