Expression And Significance Of P-gp And MRP In Esophageal Or Cardiac Carcinoma

Objectives: The esophageal and cardiac carcinomas are very common malignant tumors in China. Chemical treatment is the chief method to control the relapse and the transference after operation or as a palliative therapy. Nowadays, the effect of the drug treatment is not very effective. The main reason is the multidrug resistance (MDR) of the tumor cells. The phenotype of MDR can be divided into natural resistance and acquired induced resistance. The P-gp and MRP are the most important factors. Since the P-gp and MRP were detected, lots of investigations have been made in tumors to attempt to find some relationships with the factors such as clinical staging, pathology type and so on. But the results are quite different. Our study meant to investigate the relationships of them and the association with the factors such as clinical staging, lymphatic metastasis, infiltration depth, pathology type, et al. We hope to forecast the MDR type of the individuals, so that we can avoid using the MDR associated drugs, and apply the individualized chemotherapy to the patients to improve the specificity and then the effect of the treatment.Methods: we collected 133 samples from the patients who underwent the esophageal or cardiac carcinoma surgical resection, and the samples were taken from both tumor site and paracancerous tissues in the First Affiliated Hospital of ZhengZhou University and the Fifth Affiliated Hospital of ZhengZhou University , and they were all confirmed pathologically. The 69 esophageal squamous carcinomas and 64 cardiac adenocarcinomas were included. There were 77 male and 56 female patients, from 33 years old to 72 years old, and the median age was 56.6 years old. The surrounding...