Association Between Susceptibility To Guillain-Barre Syndrome And HLA-DQB1

Background and Objective: Guillain-Barre Syndrome, known as acute inflammatory demyelinating polyneuropathy, has been the most frequent cause of acute flaccid paralysis after poliomyelitis abolished. The classical manifestation of GBS is acute onset, speedy deterioration of symmetric weakness,decreased tone of muscle and declined or abolished tendon reflex. The CSF often shows a characteristic abnormality, with increased protein concentration but a normal cell count, which means protein-cell disassociation; but abnormality may not be found in the first week. Electrophysiology studies may reveal marked slowing of motor and sensory conduction velocity. We can have evidence of demyelination of peripheral nerves by biopsy technique. Overwhelming numbers of studies shows that GBS is a kind of autoimmune disease.It is found that in 4 weeks preceding the onset of GBS ,nearly 2/3 of GBS patients have respiratory or gastrointestinal infection .And antibodies to ganglioside such as anti-GQ1b in MFS(Miller-Fisher Syndrome),anti-GM1 or GD1a in...