Ginkgolide B Promotes And Protects The Growth And Development Of Embryonic Rat Spinal Cord Neurons In Vitro

Spinal cord injury is a kind of serious diseases that endangers people's health. There was a reported incidence rate of 20-40 per million porpulation due to traffic accidents, falling, violence, physical exercise and so on. Recently there is an ascending trend in the incidence rate. As evidenced by the poor neurologic recovery after most spinal cord injuries and the paucity of pharmacologic treatments currently available, it should be obvious to even the most casual observer that our present understanding of these pathophysiologic processes and how to manipulate them is fairly rudimentary.The death of neuronal cells from primary and secondary injuries results in complete loss of the sensory, voluntary motor, and autonomic nervous system below the site of injury. Individuals with trauma to the spinal cord often suffer from paraplegia or quadriplegia. And the high expenses on treatment and care bring a heavy burden to the relatives of the patients and the society. It is reported that traumatic injury of the spinal cord initiates a series of cellular and molecular events that include both primary and secondary injury cascades. Secondary injury may contribute significantly to the neuropathology associated with the initial injury that cause extensive demyelination and axonal destruction. Neuronal and glial cell death, delayed waves of oligoden-drocyte degeneration with morphological features suggestive of apoptosis is a major component of secondary injury and play a central role in regulating the pathogenesis of acute and chronic spinal cord injury (SCI). And it is suggested that it is with great significance to find the medicine which can decrease the neuronal cell apoptosis and protect the survival cells.Recently many researches are focused on the protective effects of Ginkgolide B...