| Curcumin is a natural active constituent extracted from Curcuma longa, which is known to have a variety of antitumor activities with few side effects. Curcumin, with poor solubility in water, can be absorbed little by the gastrointestinal tract, and its oral bioavailability is very low. Self-microemulsion drug delivery system (SMEDDS) is a kind of new drug delivery system. It has been used as a vehicle to improve the absorption of drug. So it is really a meaningful thing to study the oral solid SMEDDS of curcumin.The basic components of the formulation were determined by investigating the saturated solubility of curcumin in various medium and the interaction between oils, surfactants, and cosurfactants. The pseudoternary phase diagram of microemulsion (ME) and SMEDDS were drawn to determine the ME area. The solubility of curcumin and average particle were selected as the response variables to optimize the SMEDDS formulation and the final formulation (containing emulsifying agent OP/EL-40 (1 : 1, W/W) 57.5%, PEG400 30%, ethyl oleate 12.5%) had been found. The processing factors that affect the self-microemulsifying ability of SMEDDS had been studied. The final process was stirred with a magnetic stirrer at the speed of 400 r·min-1 for 20 minutes at 37℃. And then amylum, mannitol, and citric acid were used...
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