Study Of Aspirin Resistance After Off-Pump Coronary Artery Bypass Surgery

Background and Objective: Coronary artery bypass grafting(CABG) is one of popular option in the treatment of coronary artery disease. Aspirin is commonly used as antiplatelet treatment after operation.Recently,several studies have suggested that a significant proportion of patients(up to 45%)may not respond to aspirin with sufficient inhibition of platelet function and obtain less benefit with respect to cardiovascular events.Aspirin resistance may responsible for this phenomenon.Study from Zimmermann has shown that the majority of patients who undergo coronary artery bypass grafting develop aspirin resistance within the first 10 days after surgery.Off-pump coronary artery bypass grafting(OPCABG) is believed to reduce cardiopulmonary bypass(CPB) related complications, including platelet damage.A hypercoagulable state instead of coagulopathy has been reported following OPCABG surgeries due to CPB. Effective antithrombosis therapy is more important for patients who undergo OPCABGResearch of Poston RS have suggested that aspirin resistance and relatively compromised venous endothelial cell integrity together marked patients whose vein grafts failed within days after off-pump coronary artery bypass grafting. To investigate whether patients who underdo Off-pump coronary artery bypass grafting develop aspirin resistance after surgery, and establish adequate antithrombotic strategies,decrease the risk of thrombosis,is of particular importance for the patency of coronary anastomosis.Methods: 30 patients with coronary artery disease ,requiring CABG...