Primary Study Of Antifungal Activities And Mechanism Of Reversal Of Fluconazole Resistance Of Plagiochin E

In recent years, with the increment of HIV-infected individuals, the widespread use of immunosuppressive therapy and broad-spectrum antibiotics, the incidence of fungal infections has been increasing dramatically, especially in the immunocompromised patients. One of the major reasons that contribute to the difficulty of fungal infections treatment is the limited utilities and toxic effects of the available drugs. Another reason is the emergence of antifungal resistance, which has important implications for morbidity and mortality of fungal infections. The escalating in the number and spectrum of fungal infections as well as the clinical severity of fungal infections caused by resistant pathogens highlight the research of underlying molecular mechanisms of fungal resistance, and attracted new interests in the development of new compounds with antifungal activity.Plagiochin E, a bisbibenzyl compound, which was extracted from Marchantia polymorpha.L, showed obvious effects against Candida albicans in the primary screen assay. In this study the antifungal activity of Plagiochin E was evaluated against the isolates of C. albicans. The interactions of fluconazole with Plagiochin E against the sensitive and resistant strains were also investigated. Consequently, the mechanism on reversal of fluconazole resistance of Plagiochin E was elucidated primarily.A broth micro-dilution method in accordance with the National Committee for...