| Part â… The studying of relationship between tumor infiltrating T lymphocyte and the 5-year-survival rate of thepatients with non-small-cell lung cancer ObjectiveLung cancer is one of the leading causes of cancer in many countries. although it's diagnostic and theraprutic technology is improving, the rate of it's 5-year-survival is still very low. So it is important to study the relationship between the facts and the tumor prognosis for improving the 5-year-survival rate of lung cancer patients. In a variety of human cancers(for example esophageal cancer, pancreatic cancer, colorectal and cancer), the number and the subset of the tumor-infiltrating T lymphocytes (TILs) are considered to play important roles in anti-cancer immunomechanisms of the tumor-bearing host. However, the study about the relationship between the number of TILs and non-small-cell lung cancer (NSCLC) is very few, especially between CD4~+, CD8~+T lymphocytes and NSCLC. The study about the relationship between CD4~+, CD8~+, CD25~+ T lymphocyte and the 5-year-survival rate of patients with NSCLC have not been reported.In order to search an effective method and reasonable therapy way to promote the 5 years survival rate for lung cancer, we studied the the number, subsets of TILs in lung cancer patients and their 5-year-survival and prognosis. Firstly, we collected the cases who underwent surgical resection for lung cancer 5 years ago, and conformed whether they are survival or died by telephone. Then, tissue specimens resected from the patients were immunohistochemically analyzed for CD4, CD8 and CD25 expression. Furthermore, we analyzed the relationship between the number, sub-set of TIL and the 5-year-survival rate of NSCLC.Methods1. The clinical data of Collected cases... |
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