The Expression And Significance Of COX-2 And TGF-β1 In Chronic Hepatitis B And Cirrhosis Patients

Objective Chronic hepatitis B is one of the most prevalent infectious diseases in the world. Some people would develop into liver fibrosis and cirrhosis. At present, the activation of hepatic stellate cell (HSC) is regarded as the key step of hepatic fibrosis. The process of stellate cell activation is complex. Many cytokines play important roles in this process, especially cyclooxygenase (COX), transforming growth factor- β 1 (TGF-β1) and platelet derived growth factor(PDGF). The aim of this study is to investigate the roles of COX-2 and TGF-pi in process of inflammatory injury and fibrosis by observing the expression of COX-2 and TGF-β1 in chronic hepatitis B and cirrhosis patients.Materials and Methods Hepatic tissues from 40 patients with chronic hepatitis B and 20 patients with cirrhosis and 5 normal were detected by immunohistochemical methods.Result ?It was investigated that there were no or little expression of COX-2 in normal hepatic tissues. The positive rate and intensity of COX-2 expression were more evident in the hepatic tissues of chronic hepatitis B patients and cirrhotic patients than in the tissues of control group people(P< 0.005).And the expression of COX-2 was more evident in the liver of chronic hepatitis patients than in the liver of cirrhotic patients (P <0.05). The intensity of COX-2 expression had significant differece...