Clinical And Pathological Study On IgA Nephropathy With The Deposition Of Hepatitis B Virus Antigens In Renal Tissue

Objectives1, To investigate the clinical and pathological characteristic;2, To evaluate whether there existed different subtypes of IgA nephropathy with the deposition of HBV antigens in renal tissue, and the pathological characteristics of it.MethodsRetrospective study method was applied to analyze 120 IgA nephropathy accompanied by the deposition of HBV antigens and IgA nephropathy without deposition of HBV antigens. The control study was performed on clinical classification, histomorphology, immunological type, ultrastructure. The relevant factors were scored by semiquantitative analysis.Results1,Group A(37.5%) with massive proteinuria and nephrotic syndrome was significantlydifferent from group B(19.17%)(P<0.05)and group A with haematuriu (7.5%) wassignificantly different from group B( 19.17%)(P<0.05).2,Pathological Lee's classification of renal tissue: grade IV in group A(27.14%) wassignificantly higher than in group B(8.33%)(P<0.05),while grade II in group A(18.83%)was significantly lower than in group B(47.5%)(P<0.05). There was significantly moresclerosis of glomcrulus, atrophia of tubules and fibrosis of interstitium in group A thanthose in group B. (P<0.05)3,Immunohistochemical result: group A(60.0%) with IgA+IgG+IgM was significantlyhigher than group B(28.33%)(P<0.05); while group B(32.0%) with IgA+IgG wassignificantly higher than group A(10.83%)(P<0.05)...