| Background and objectiveIschemic heart disease continues to be the most common cause of cardiac death.Although thrombolysis, PTCA or CABG are established methods to achieve reopening of an occluded vessel in patients with acute myocardial infarction,myocardial ischemia-reperfusion injury significantly compromises myocardial function.Therefore,the investigation of strategies for the amelioration or preservation of myocardial cell viability has been a matter of great interest in both clinical and experimental settings.It was found that resveratrol has antioxidant,free radical scavenging and apoptosis inhibiting properties,which are relevant to the cardioprotective effects of resveratrol in preventing atherosclerosis and coronary heart disease.In the last few years,most of the studies considered so far concentrated on the cardioprotective effects of resveratrol.Interestingly, resveratrol has been identified recently as one of the strongest stimulators of silent information regulator 2(SIR2) enzymes in vivo and in vitro,and this property has been proposed to account for its anti-aging effects.We investigated the effect of resveratrol on SIR2 and Caspase3 expression and cardiomyocyte apoptosis induced by ischemia- reperfusion in rats.MethodsMale Sprague Dawley rats were divided randomly into sham-operated, ischemia reperfusion and resveratrol-treated groups(group1, group2 and group3) with 10 rats in each group. The left main coronary artery was occluded for 30min followed by a 2-h... |
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