Effect Of Shenfu On The Dose And Time-Effect On Myocardium Protection Druing Cardiopulmonary Bypass

Objective: To explore effect of Shenfu injection ( SFI ) the dose and time-effect relationship Shenfu injection ( SFI ) on myocardium protection in mitral valve replacement ( MVR ) druing cardiopulmonary bypass ( CPB ) so as to support further theory evidence for clinical prper medcation.Methods: 40 patients ( ASAⅡ～Ⅲ, NYHAⅡ～Ⅲ, 38～50 years ) undergoing elective MVR were randomized into control group ( group C ) and trial groupsâ… ,â…¡andâ…¢. Patients in group C accepted normal saline during whole CPB. Trial groupsâ… ,â…¡andâ…¢were respectively put into with SFI 1.0 ml/kg, 1.5ml/kg and 2ml/kg at the time of routine primiing fluiding as well as after opening aorta. MAP was monitored before CPB ( t₁ ), at times of initiating anterior parallel circulation ( APC ) ( t₂ ), of posterior parallel circulation ( PPC ) ( t₃ ) and CPB stopping ( t₄ ). Other henmodynamics markers ( HR, rate of spontaneous heart beat and cardiac rhythm ) were recorded after restoration of heart beat. Blood samples were taken from central vein to determine the serum concents of cardiac neuropeptide Y ( NPY ) , cardiac troponin I ( cTnI ) and the activity of glutathione peroxidase ( GSH-PX ) in each group respectively before the operation ( T₀), at the time of termination of operation ( T₁) and 3 hours ( T₂ ), 24 hours ( T₃ ) after operations. And diversity rates of three indexes...