| Objective: To evaluate the effect of posterolateral lumbar spinal fusion with allograft and rhBMP-2 composite in a rabbit model. Method: Thirty rabbit were randomly divided into three groups: Autogenous iliac crest bone graft group, rhBMP-2/allograft composite group, Allograft group. The lumbar intertransverse process fusion were assessed by manual palpation, biomechanical testing, radiography, histology and quantitative histology of spine fusion masses in 6-week observation. Result: The ratio of fusion in rhBMP-2/allograft composite group were significantly superior to autogenous iliac crest bone graft group and allograft group. The autogenous iliac crest bone graft group and rhBMP-2/allograft composite group showed significantly higher uniaxial tensile strength than allograft group. The autogenous iliac crest bone graft group and rhBMP-2/allograft composite group also showed significantly more new bone form than allograft group, but there are no difference in former two groups. Conclusion: rhBMP-2/allograft composite may be ideal substitution for autograft in lumbar spinal fusion. |
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