| Objective: To investigate the protective effects of Arnebia euchroma (Royle) Johnston extracts (fat-soluble extract, AE- I ; water-soluble extract, AE- II) against experimental liver injury in mice. Methods: The experimental animal models of liver injury were established by intraperitoneal injection of 0.1% carbon tetrachloride (CCl4) olive oil 10ml/kg, by intraperitoneal injection of 10% D-galactosamine (D-GalN) 1000mg/kg, by caudal vein injection of Bacillus Calmette Guerin (BCG) plus lipopolysaccharides (LPS) and by alcohol through consecutive gastric infusion in mice respectively. The liver and spleen indexes; alanine aminotransferase (ALT), aspartate amiontransferase (AST), cholesterol (CHO) and triglycerides (TG) activities in serum; superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, malondialdehyde (MDA) and nitric oxide (NO) contents in liver homogenate; and the histopathological changes of the liver were assayed. Results: (1)In chemical hepatitis animal model induced by CCl4, both AE- I and AE- II significantly decreased the activities of serum ALT and AST (P<0.01), and improved the histopathological changes in different degrees; AE- I (0.8g/kg) increased the activities of liver homogenate SOD, GSH-Px and decreased the content of MDA (P<0.05); AE- I (0.4g/kg) increased the activity of liver homogenate GSH-Px (PO.05); AE- II (4g/kg) decreased the content of MDA (P<0.05). (2) In chemical hepatitis animal model induced by... |
PDF Full Text Request