| Research background:Chronic asymptomatic HBV carriers (AsC) are HBV infectors who have neither symptoms, signs nor change of liver function. Therefore, among them, only very few are accidentally diagnosed. Our country is a high incidence area of HBV infection with a large number of AsC. AsC serves as the source of infection to make easily infected group new HBV infectors through mother-baby transmission, iatrogenic infection, blood and blood product pollution, child-to-child transmission and sexual transmission. In China, over 0.3 billion people have ever been infected with HBV and the number of AsC is up to 0.1 to 1.2 billion. In addition, a lot of chronic hepatitis B (CHB ) breaks out due to pathological changes of AsC and can further develop into liver cirrhosis (LC) or even hepatic cellular cancer (HCC) . Among a variety of therapies for AsC, Traditional Chinese medicine (TCM) treatment possesses particular advantages. However, until now the effect of the AsC therapy has not obtained universal recognition due to the reasons such as bad repetition. The treasure of Chinese medical works is preventive treatment theory and it is decisively influential in therapeutic effect whether the thought of early treatment to prevent deterioration is concretely applied. Hence, doing research on AsC therapy must first start with the concept of peventive treatment. Purpose:In terms of the difficulty in no symptom of AsC clinically, based on supervisor' s clinical experiences from years of practice, this study believes because of poor immunity function, AsC cannot be immunized from HBV. With a holistic view, to strengthen organic immunity function,the top priority is to nurse liver and spleen, which can fundamentally change HBV infected status and enhance the effect of Chinese medicine therapy for AsC clinically. Study objects and method:Seventy-five cases of AsC included in the study are divided into a treatment group of forty-five cases and a contrast group of thirty cases. Carry on investigations and keep records respectively, apply two different medications and check blood serum to observe the change of indicators before and after the treatment.Adopt statistic software SPSS to proceeding single factor analysis and non-parameter statistics, analyzing the relationship of the effects of two groups and each observing indicator and discussing whether there are differences after recovery owing to the difference of sex, age, course of disease, life habit and physique. Outcome:1. Two groups of observed cases, after two courses of treatment, are examined into their blood serum and it is found that no matter the positive rate of HBV indicators or HBV-DNA quantity detecting partially turn negative. For a decreasing proportion of the positive rate of HBV indicators, the difference between the treatment group and the contrast group is obvious.(33.3 % and 6.7 % > P<0.05 )For the rate of turning negative of HBV-DNA quantity detecting, at the end of the first treatment, the difference between two groups is very obvious. (20 % and 0, P<0.01);at the end of the second treatment, the difference in effect between the two is still obvious. (35.6% and 13.3%, P<0.05)2. According to the difference of sex, age and course of disease, compare how HBeAg and HBV-DNA change before and six monthes after the treatment. Except the comparison among different courses of disease, indicating that the effect of more than three-year course of disease is strikingly influential, under other conditions, the rate of HbeAg and HBV-DNA turning negative is not obviously different. (P>0.05)3. According to the difference of living surroundings and physiques, compare how HBeAg and HBV-DNA change before and six monthes after the treatment. It is found that the rate of HbeAg and HBV-DNA turning negative is not obviously different. (P>0.05) These might relate to the factors such as relatively inadequate samples and short observing time under different conditions.Conclusion:At the initial stage of a AsC, the thought of preventive treatment should be followed. Make every effort to achieve early diagnosis, early treatment and prevent disease transformation and transmission. Because HBV lurks in a liver, it is the key to pathogenesis that healthy qi cannot overcome pathogenic factors. The positions of disease are mainly liver and spleen.Thus, the general therapeutic principle is to strengthen healthy qi to eliminate pathogenic factors and to regulate zang-viscera and fu-viscera of the body.Moreover, acquired factors are very crucial for condition and development of individual healthy qi. Use the change of living surroundings, diet, necessary methods of forging and cultivating health and TCM of strengthening immunocompetence to gradually correct the aptitude for physique, accelerate compensation mechanism to prevent diseases or enhance health to facilitate immunoreation to prevent the disease from transforming after its outbreak.Due to the limitation of study conditions, this thesis is applied to distinguishing the treatment group among different conditions. Comparison on the rates of HbeAg and HBV-DNA turning negative does not correspond to the statistical difference because of the relative lack of samples. However, it is a worthwhile research approach to adopt the thought of preventive treatment to conducting AsC treatment, which is the creative outcome of this thesis.
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